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OCR: ction of Fig. 17.11 shows the mechanism of inter t TSH with TSH-R(s) antibodies. The targ The gene autoantigen in patients with Graves' ophthalmopathy remains controversial, e muscle for a 64-kDa membrane protein of the ey o this has recently been cloned. IgG antibodies an sera, antigen are found in many normal hum tected in although increased concentrations are d ents. The the sera of Graves' ophthalmopathy pati ent naturalanti-64kDa antibodies may merely repre autoantibodies that react with recurrent autoepitopes.